Introduction: Coding Life (01:44)
CRISPR technology allows for genomic rewriting, resulting in a genetic engineering revolution. Viruses are reprogrammed to kill cancer cells. The science has become publicly accessible.
Facioscapulohumeral Muscular Dystrophy (01:46)
Ivan van der Meij describes growing up with a genetic disease while playing a video game. His condition will progress as he ages. His mother expresses concerns over new medicine effectiveness and timeliness.
Genetic Pioneers (04:51)
Emmanuelle Charpentier collaborated on CRISPR Cas9. She recalls a 2010 meeting of leading scientists and development benchmarks. CRISPR-technology is based on Microbiologist John van der Oost's bacterial studies.
Bacterial Defenses (02:26)
CRISPR technology was discovered in bacteria. Subject to viruses, they evolve Clustered Regularly Interspaced Short Palindromic Repeat as protection. Scientists replicate the process, allowing precise editing of genetic codes.
Hubrecht Laboratory (04:50)
Meij's disease results from genetic abnormality; CRISPR has potential to cure him. He and his mother consult with Cell Biologist Niels Geijsen; the technology enables expedient studies.
Building Biological Circuits (03:55)
Biotechnologist Andrew Hessel describes problems with traditional disease and treatment studies and discusses digital control of DNA. CRISPR allows reading, writing and reprogramming of A,T,G,C sequences. He explains functionalization of codes, and cutting and pasting genetic components.
Josiah Zayner sells CRISPR kits online for home experiment. He asserts universal interest in genetic engineering. Zayner discusses "cool" human modifications.
Humane Genomics (04:44)
Hessel explains goals of digitizing biological tools; his company aspires to create personalized cancer medications. The company partners with Auburn University College of Veterinary Medicine, building the first synthetic canine cancer cure in 2016. Hessel discusses the future of oncology.
Ethical Concerns (04:56)
Zayner explains CRISPR kit components; gene alteration experiments have expanded. Charpentier discusses principles for the technology's use. Waag Biohack Academy offers a basic course.
Business Aspects (04:14)
John van der Oost owns a CRISPR component patent; he markets it in Boston. He does not know a potential buyers' intentions for its use. CRISPR could cure an estimated 3,000 diseases.
Waag Biohack Academy (04:27)
Biohackers in Amsterdam discuss societal concerns before conducting the final CRISPR kit step. Altering genetics is not legal. Charpentier explains how variation of international laws makes technology regulation difficult.
Open Source Knowledge (03:01)
Zayner defends popularizing genetic engineering technologies. Hassel discusses ease of procuring tools and knowledge accelerating his studies. Meij and his mother confer with Geijsen regarding when to expect results.
Credits: Coding Life (00:29)
Credits: Coding Life
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