Beginning the 1970s, researchers realized that cancer is caused by several gene mutations and environmental factors. The understanding has led to newer treatment methods. The drug Gleevec targets the abnormality that causes leukemia and stops its cell growth.
The medical community believed cancer was caused by an infection until it was discovered to be a gene mutation. The gene was a proto-oncogene that helps cells divide and grow. When it mutates into a RAS oncogene, it can convert other cells into cancer cells.
Numerous gene mutations, some of which happen naturally, must occur for cancer to develop. Tumor suppressor genes stop mutated cells from dividing, but cancer breaks down the process. The p53 protein is altered in various types of cancers.
Understanding how a normal cell moves through the cell cycle is important for researchers studying cancer. Dr. Leland Hartwell was able to illustrate the process using yeast.
The telomere is protective cap for the DNA on the end of a chromosome, which is not fully copy after each cell replication. An enzyme called telomerase continues the telomere replication in cancer cells. Telomerase is a possible target for future cancer treatment.
Credits: Cell Biology and Cancer
For additional digital leasing and purchase options contact a media consultant at 800-257-5126 (press option 3) or email@example.com.
Cancers result when genes required for normal cell function are mutated and the resulting cells undergo other changes ultimately leading to uncontrolled division. This session reveals new information on normal cell function, proto-oncogenes and tumor suppressor genes and their role in the cell cycle, and current research in drug design for specific cancers.
Length: 29 minutes
Copyright date: ©2003
Prices include public performance rights.
Not available to Home Video, Dealer and Publisher customers.
How Do We Test for Biological Molec...
What is the Diffusion of Molecules?
What is Mitosis and Meiosis?
Episode 6: Heat and the Human Body
The Immortal Life of Henrietta Lack...
Our Genes Under Influence
Rediscovering Biology: Molecular to...
Genetics of Development
The Energy of Life
132 West 31st Street, 16th Floor
New York, NY 10001
P: 800.322.8755 F: 800.678.3633
Sign Up for Special Offers!
© Films Media Group. All rights reserved.